Gianpaolo Papaccio - Top Italian Scientist in Biomedical Sciences
Full professor of Histology and Embryology, Department of Experimental Medicine. Director
of the TERM lab. Co-director in the CGA (Centro Grandi Apparecchiature) and BioTecknet.
Director of the Laboratory: Tissue Engineering, Regenerative Medicine and Cancer Stem cell
Director of Hospital Unit of Diagnostics in Cytometry and Molecular Oncology (Deep
Scientific activity: : Mesenchymal Stem Cells differentiation into bone and Cancer Stem Cells of osteosarcomas and oral cancer.
In particular, he studied: -mesenchymal stem cells, characterizing a subpopulation, called SBP-DPSCs which has
demonstrated capability to produce woven bone in vitro. Moreover, he has studied their interactions with scaffolds and
tissue formation in engineerized rotating apparatuses. Studies led to the production of a bone tissue in vivo. The
studies were then enlarged and applied to humans leading to a successful clinical trial in which mandible bone defects
were completely restored. Moreover, he is studying other than the applications of DPSCs, adult Mesenchymal cells of
human adipose tissue, with the production in vitro and in vivo of a loose adipose, vascularized connective and other
tissues. Mesenchymal stem cells were also loaded on several scaffolds and in 3D their behavior was studied. The
ability to drive differentiation has been evidenced. In addition, he studies the cancer stem cells (CSCs) in
osteosarcomas. He identified those cells using the CD133 marker and other techniques, then after transplantation
into NOD/SCID mice obtained tumours with the same CSCs. Studies on CSCs and compared those cells when
forming spheres with adherent ones from sarcomas and oral cancer. Another interesting topic regards the
studies of interaction of CSCs with adipose stem cells. Articles on those topics have been published to International
Journals with IF. Two International patents have been also obtained and extended worldwide. Studies on several
aspects of cancers have also been published.Referee of several Journals, including:
Stem Cells; Tissue Eng; Cancer Res; Int. J. of cancer;
FEBS letters; JBMR; Cell Death and Differentiation; BMC central; PLOS One; Stem Cells Rev;
ECM J; Biomaterials; J Cell Physiology; J Cell Biochem; Bone; Gene Ther; J Cell Biochem., Cytotherapy, Stem cell
Rev rep; Stem Cells and Regen, frontiers in Physiol; Oncotarget.
Member of the Editorial Board and Top Reviewer of the following International Journals:
-Stem Cells Transl Med
-Plos One; Journal of Dental
research; Stem Cell Reviews
Letters, Stem Cells in Oral
Biology; Cells;Int J Mol Sci
cancer stem cells
mesenchymal stem cells
Università degli Studi della Campania "Luigi Vanvitelli"
|Macroarea: Biomedical Sciences
Italian Institution(s): Università degli Studi della Campania "Luigi Vanvitelli"